Posts in Jatin Roper

Cross-species analysis of genetically engineered mouse models of MAPK-driven colorectal cancer identifies hallmarks of the human disease.

Belmont PJ, Budinska E, Jiang P, Sinnamon MJ, Coffee E, Roper J, Xie T, Rejto PA, Derkits S, Sansom OJ, […]
by Jatin Roper
on Jan 5
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Combination PI3K/MEK inhibition promotes tumor apoptosis and regression in PIK3CA wild-type, KRAS mutant colorectal cancer.

RoperJ, Sinnamon MJ, Coffee EM, Belmont P, Keung L, Georgeon-Richard L, Wang WV, Faber AC, Yun J, Yilmaz ÖH, Bronson […]
by Jatin Roper
on Jan 5
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RAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1.

Faber AC, Coffee EM, Costa C, Dastur A, Ebi H, Hata AN, Yeo AT, Edelman EJ, Song Y, Tam AT, […]
by Jatin Roper
on Jan 5
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Concomitant BRAF and PI3K/mTOR blockade is required for effective treatment of BRAF(V600E) colorectal cancer.

Coffee EM, Faber AC, Roper J, Sinnamon MJ, Goel G, Keung L, Wang WV, Vecchione L, de Vriendt V, Weinstein […]
by Jatin Roper
on Jan 3
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Development of a colon cancer GEMM-derived orthotopic transplant model for drug discovery and validation.

Martin ES, Belmont PJ, Sinnamon MJ, Richard LG, Yuan J, Coffee EM, Roper J, Lee L, Heidari P, Lunt SY, […]
by Jatin Roper
on Jan 3
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Priceless GEMMs: genetically engineered mouse models for colorectal cancer drug development.

RoperJ, Hung KE. Priceless GEMMs: genetically engineered mouse models for colorectal cancer drug development. Trends Pharmacol Sci. 2012 Aug;33(8):449–55. PMID: […]
by Jatin Roper
on Jan 3
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The effect of H. pylori eradication on meal-associated changes in plasma ghrelin and leptin.

Francois F, Roper J, Joseph N, Pei Z, Chhada A, Shak JR, Olivares A, Perez-Perez GI, Blaser MJ. The effect […]
by Jatin Roper
on Jan 3
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The dual PI3K/mTOR inhibitor NVP-BEZ235 induces tumor regression in a genetically engineered mouse model of PIK3CA wild-type colorectal cancer.

Roper J*, Richardson MP*, Wang WV, Richard LG, Chen W, Coffee EM, Sinnamon MJ, Lee L, Chen P, Bronson RT, […]
by Jatin Roper
on Jan 3
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The association of gastric leptin with esophageal inflammation and metaplasia.

Francois F, Roper J, Goodman A, Pei Z, Mourad M, Olivares de Perez A, Perez-Perez GI, Tseng CH, Blaser MJ.  […]
by Jatin Roper
on Jan 3
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Leptin and ghrelin in relation to Helicobacter pylori status in male veterans.

Roper J, Francois F, Shue PL, Mourad M, Pei Z, Olivares AZ, Perez-Perez GI, Tseng CH, Blaser MJ.  Leptin and […]
by Jatin Roper
on Jan 3
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